Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells

Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells

Hydrogen sulfide (H<sub>2</sub>S), synthesized by cystathionine gamma-lyase (Cth), contributes to the inflammatory response observed in sepsis. This study examines the effect of Cth-derived H<sub>2</sub>S in adhesion molecules on endothelial cells of vital organs in mice in a...

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Bibliographic Details
Main Authors: Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogen sulfide
cystathionine gamma-lyase
sepsis
adhesion molecules
endothelial cells
Online Access:https://www.mdpi.com/1422-0067/24/17/13650

Internet

https://www.mdpi.com/1422-0067/24/17/13650

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