Food-Derived Hemorphins Cross Intestinal and Blood–Brain Barriers In Vitro

Food-Derived Hemorphins Cross Intestinal and Blood–Brain Barriers In Vitro

A qualitative study is presented, where the main question was whether food-derived hemorphins, i.e., originating from digested alimentary hemoglobin, could pass the intestinal barrier and/or the blood–brain barrier (BBB). Once absorbed, hemorphins are opioid receptor (OR) ligands that may interact w...

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Bibliographic Details
Main Authors: Dorothée Domenger, Benoit Cudennec, Mostafa Kouach, Véronique Touche, Christophe Landry, Jean Lesage, Fabien Gosselet, Sophie Lestavel, Jean-François Goossens, Pascal Dhulster, Rozenn Ravallec
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Endocrinology
Subjects:
opioid peptides
hemorphins
intestinal barrier
blood–brain barrier
Caco-2 model
brain-like endothelial cell model
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00159/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00159/full

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