Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways

Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways

Degenerative disc disease (DDD) is an important cause of low back pain. Repetitive tensile stress from the daily motion of the spine predisposes it to injury of the annulus fibrosus (AF) which causes IVD degeneration. This study aims to determine the causal relationship between mechanical stretch an...

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Bibliographic Details
Main Authors: Cheng-Nan Chen, Hsin-I Chang, Chia-Kung Yen, Wen-Lung Liu, Kuo-Yuan Huang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
degenerative disc disease
tensile stress
bone morphogenetic protein-2/6 (BMP-2/6) heterodimers
osteogenesis
p38 MAP kinase pathway
BMP-SMAD1/5/8 signaling
Online Access:https://www.mdpi.com/2073-4409/11/16/2600

Internet

https://www.mdpi.com/2073-4409/11/16/2600

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