Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro
Mutations in superoxide dismutase 1 (SOD1) are found in approximately 20% of patients with familial amyotrophic lateral sclerosis. The propensity of mutant SOD1 to form aggregates in pathologically affected cells (i.e. motor neurons) has implicated these poorly soluble protein aggregates and/or thei...
| Prif Awduron: | , , |
|---|---|
| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
Elsevier
2013-01-01
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| Cyfres: | Neurobiology of Disease |
| Pynciau: | |
| Mynediad Ar-lein: | http://www.sciencedirect.com/science/article/pii/S0969996112002975 |