Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Both substance use disorder and HIV infection continue to affect many individuals. Both have untoward effects on the brain, and the two conditions often co-exist. In the brain, macrophages and microglia are infectable by HIV, and these cells are also targets for the effects of drugs of abuse, such a...

Descripció completa

Dades bibliogràfiques
Autors principals:	Meng Niu, Brenda Morsey, Benjamin G. Lamberty, Katy Emanuel, Fang Yu, Rosiris León-Rivera, Joan W. Berman, Peter J. Gaskill, Stephanie M. Matt, Pawel S. Ciborowski, Howard S. Fox
Format:	Article
Idioma:	English
Publicat:	MDPI AG 2020-11-01
Col·lecció:	Viruses
Matèries:	HIV SIV neuroHIV HIV-associated neurocognitive disorders (HAND) macrophage microglia
Accés en línia:	https://www.mdpi.com/1999-4915/12/11/1297

Ítems similars

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
per: Howard S. Fox, et al.
Publicat: (2022-11-01)

A Rationale and Approach to the Development of Specific Treatments for HIV Associated Neurocognitive Impairment
per: Aaron Scanlan, et al.
Publicat: (2022-11-01)

Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system
per: Nikki eBortell, et al.
Publicat: (2015-09-01)

Editorial: Advances in Understanding NeuroHIV Associated Changes in Neuroimmune Communication in the Combined Anti-retroviral Therapy (cART) Era
per: Peter J. Gaskill, et al.
Publicat: (2021-10-01)

Co-receptor signaling in the pathogenesis of neuroHIV
per: E. A. Nickoloff-Bybel, et al.
Publicat: (2021-08-01)

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
per: Rachel M. Podgorski, et al.
Publicat: (2023-08-01)

Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats
per: Yu Fu, et al.
Publicat: (2022-03-01)

Dopamine Levels Induced by Substance Abuse Alter Efficacy of Maraviroc and Expression of CCR5 Conformations on Myeloid Cells: Implications for NeuroHIV
per: Stephanie M. Matt, et al.
Publicat: (2021-05-01)

Pitfalls of Antiretroviral Therapy: Current Status and Long-Term CNS Toxicity
per: Harrison Rudd, et al.
Publicat: (2022-06-01)

Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain
per: Maribel Donoso, et al.
Publicat: (2022-08-01)

HIV-1 Tat alters neuronal intrinsic excitability
per: Walter Francesconi, et al.
Publicat: (2018-05-01)

Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
per: Caitlin Tice, et al.
Publicat: (2020-09-01)

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
per: Lindsay K Festa, et al.
Publicat: (2020-01-01)

Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities
per: Seema Singh, et al.
Publicat: (2024-05-01)

Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder
per: Chloe E. Meehan, et al.
Publicat: (2023-10-01)

Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex
per: Congwu Du, et al.
Publicat: (2022-05-01)

Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV
per: Mikki Schantell, et al.
Publicat: (2021-01-01)

Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV
per: Michael Ilya Bukrinsky
Publicat: (2025-03-01)

Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.
per: Jean Marie eAndrieu, et al.
Publicat: (2014-06-01)

Bioinformatics Study of the Interaction between Melittin Protein and P24 Protein in HIV and SIV Viruses
per: Zahra Hasanshahi, et al.
Publicat: (2022-11-01)

The fourth major restriction factor against HIV/SIV
per: Masako eNomaguchi, et al.
Publicat: (2011-06-01)

HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age
per: Christina E. Khodr, et al.
Publicat: (2022-07-01)

Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail
per: Takeo eKuwata, et al.
Publicat: (2013-05-01)

Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
per: Carol L. Vinton, et al.
Publicat: (2020-04-01)

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
per: Vijayakumar Velu, et al.
Publicat: (2018-06-01)

SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo
per: Nina Derby, et al.
Publicat: (2024-02-01)

Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
per: Olivia Harwood, et al.
Publicat: (2021-09-01)

Association of MHC-I genotypes with disease progression in HIV/SIV infections
per: Takushi eNomura, et al.
Publicat: (2012-06-01)

Editorial: Direct and Indirect Interactions of HIV With Host Cells
per: Tetsuo Tsukamoto, et al.
Publicat: (2021-10-01)

Quantitative and Qualitative Distinctions between HIV-1 and SIV Reservoirs: Implications for HIV-1 Cure-Related Studies
per: Joseph C. Mudd
Publicat: (2024-03-01)

Innate Lymphoid Cells in HIV/SIV Infections
per: Spandan V. Shah, et al.
Publicat: (2017-12-01)

Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET
per: Swati Shah, et al.
Publicat: (2019-05-01)

TRIM5α and species tropism of HIV/SIV
per: Emi E. Nakayama, et al.
Publicat: (2012-01-01)

Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging
per: Zoey K. Wallis, et al.
Publicat: (2022-02-01)

The Youngbloods. Get Together. Hypercoagulation, Complement, and NET Formation in HIV/SIV Pathogenesis
per: Theresa A. Reno, et al.
Publicat: (2022-01-01)

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities
per: Rosiris León-Rivera, et al.
Publicat: (2020-08-01)

CTL escape and viral fitness in HIV/SIV infection
per: Sayuri eSeki, et al.
Publicat: (2012-01-01)

Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection
per: Yoelvis Garcia-Mesa, et al.
Publicat: (2021-03-01)

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells
per: Daniel Corey, et al.
Publicat: (2023-03-01)

Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques
per: Benjamin N. Bimber, et al.
Publicat: (2024-08-01)