Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Both substance use disorder and HIV infection continue to affect many individuals. Both have untoward effects on the brain, and the two conditions often co-exist. In the brain, macrophages and microglia are infectable by HIV, and these cells are also targets for the effects of drugs of abuse, such a...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Meng Niu, Brenda Morsey, Benjamin G. Lamberty, Katy Emanuel, Fang Yu, Rosiris León-Rivera, Joan W. Berman, Peter J. Gaskill, Stephanie M. Matt, Pawel S. Ciborowski, Howard S. Fox
Natura:	Articolo
Lingua:	English
Pubblicazione:	MDPI AG 2020-11-01
Serie:	Viruses
Soggetti:	HIV SIV neuroHIV HIV-associated neurocognitive disorders (HAND) macrophage microglia
Accesso online:	https://www.mdpi.com/1999-4915/12/11/1297

Documenti analoghi

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
di: Howard S. Fox, et al.
Pubblicazione: (2022-11-01)

A Rationale and Approach to the Development of Specific Treatments for HIV Associated Neurocognitive Impairment
di: Aaron Scanlan, et al.
Pubblicazione: (2022-11-01)

Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system
di: Nikki eBortell, et al.
Pubblicazione: (2015-09-01)

Editorial: Advances in Understanding NeuroHIV Associated Changes in Neuroimmune Communication in the Combined Anti-retroviral Therapy (cART) Era
di: Peter J. Gaskill, et al.
Pubblicazione: (2021-10-01)

Co-receptor signaling in the pathogenesis of neuroHIV
di: E. A. Nickoloff-Bybel, et al.
Pubblicazione: (2021-08-01)

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
di: Rachel M. Podgorski, et al.
Pubblicazione: (2023-08-01)

Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats
di: Yu Fu, et al.
Pubblicazione: (2022-03-01)

Dopamine Levels Induced by Substance Abuse Alter Efficacy of Maraviroc and Expression of CCR5 Conformations on Myeloid Cells: Implications for NeuroHIV
di: Stephanie M. Matt, et al.
Pubblicazione: (2021-05-01)

Pitfalls of Antiretroviral Therapy: Current Status and Long-Term CNS Toxicity
di: Harrison Rudd, et al.
Pubblicazione: (2022-06-01)

Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain
di: Maribel Donoso, et al.
Pubblicazione: (2022-08-01)

HIV-1 Tat alters neuronal intrinsic excitability
di: Walter Francesconi, et al.
Pubblicazione: (2018-05-01)

Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
di: Caitlin Tice, et al.
Pubblicazione: (2020-09-01)

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
di: Lindsay K Festa, et al.
Pubblicazione: (2020-01-01)

Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities
di: Seema Singh, et al.
Pubblicazione: (2024-05-01)

Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder
di: Chloe E. Meehan, et al.
Pubblicazione: (2023-10-01)

Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex
di: Congwu Du, et al.
Pubblicazione: (2022-05-01)

Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV
di: Mikki Schantell, et al.
Pubblicazione: (2021-01-01)

Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV
di: Michael Ilya Bukrinsky
Pubblicazione: (2025-03-01)

Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.
di: Jean Marie eAndrieu, et al.
Pubblicazione: (2014-06-01)

Bioinformatics Study of the Interaction between Melittin Protein and P24 Protein in HIV and SIV Viruses
di: Zahra Hasanshahi, et al.
Pubblicazione: (2022-11-01)

The fourth major restriction factor against HIV/SIV
di: Masako eNomaguchi, et al.
Pubblicazione: (2011-06-01)

HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age
di: Christina E. Khodr, et al.
Pubblicazione: (2022-07-01)

Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail
di: Takeo eKuwata, et al.
Pubblicazione: (2013-05-01)

Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
di: Carol L. Vinton, et al.
Pubblicazione: (2020-04-01)

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
di: Vijayakumar Velu, et al.
Pubblicazione: (2018-06-01)

SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo
di: Nina Derby, et al.
Pubblicazione: (2024-02-01)

Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
di: Olivia Harwood, et al.
Pubblicazione: (2021-09-01)

Association of MHC-I genotypes with disease progression in HIV/SIV infections
di: Takushi eNomura, et al.
Pubblicazione: (2012-06-01)

Editorial: Direct and Indirect Interactions of HIV With Host Cells
di: Tetsuo Tsukamoto, et al.
Pubblicazione: (2021-10-01)

Quantitative and Qualitative Distinctions between HIV-1 and SIV Reservoirs: Implications for HIV-1 Cure-Related Studies
di: Joseph C. Mudd
Pubblicazione: (2024-03-01)

Innate Lymphoid Cells in HIV/SIV Infections
di: Spandan V. Shah, et al.
Pubblicazione: (2017-12-01)

Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET
di: Swati Shah, et al.
Pubblicazione: (2019-05-01)

TRIM5α and species tropism of HIV/SIV
di: Emi E. Nakayama, et al.
Pubblicazione: (2012-01-01)

Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging
di: Zoey K. Wallis, et al.
Pubblicazione: (2022-02-01)

The Youngbloods. Get Together. Hypercoagulation, Complement, and NET Formation in HIV/SIV Pathogenesis
di: Theresa A. Reno, et al.
Pubblicazione: (2022-01-01)

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities
di: Rosiris León-Rivera, et al.
Pubblicazione: (2020-08-01)

CTL escape and viral fitness in HIV/SIV infection
di: Sayuri eSeki, et al.
Pubblicazione: (2012-01-01)

Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection
di: Yoelvis Garcia-Mesa, et al.
Pubblicazione: (2021-03-01)

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells
di: Daniel Corey, et al.
Pubblicazione: (2023-03-01)

Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques
di: Benjamin N. Bimber, et al.
Pubblicazione: (2024-08-01)