Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis
Both substance use disorder and HIV infection continue to affect many individuals. Both have untoward effects on the brain, and the two conditions often co-exist. In the brain, macrophages and microglia are infectable by HIV, and these cells are also targets for the effects of drugs of abuse, such a...
Главные авторы: | Meng Niu, Brenda Morsey, Benjamin G. Lamberty, Katy Emanuel, Fang Yu, Rosiris León-Rivera, Joan W. Berman, Peter J. Gaskill, Stephanie M. Matt, Pawel S. Ciborowski, Howard S. Fox |
---|---|
Формат: | Статья |
Язык: | English |
Опубликовано: |
MDPI AG
2020-11-01
|
Серии: | Viruses |
Предметы: | |
Online-ссылка: | https://www.mdpi.com/1999-4915/12/11/1297 |
Схожие документы
-
Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
по: Howard S. Fox, и др.
Опубликовано: (2022-11-01) -
A Rationale and Approach to the Development of Specific Treatments for HIV Associated Neurocognitive Impairment
по: Aaron Scanlan, и др.
Опубликовано: (2022-11-01) -
Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system
по: Nikki eBortell, и др.
Опубликовано: (2015-09-01) -
Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
по: Rachel M. Podgorski, и др.
Опубликовано: (2023-08-01) -
Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats
по: Yu Fu, и др.
Опубликовано: (2022-03-01)