Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis

Both substance use disorder and HIV infection continue to affect many individuals. Both have untoward effects on the brain, and the two conditions often co-exist. In the brain, macrophages and microglia are infectable by HIV, and these cells are also targets for the effects of drugs of abuse, such a...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Meng Niu, Brenda Morsey, Benjamin G. Lamberty, Katy Emanuel, Fang Yu, Rosiris León-Rivera, Joan W. Berman, Peter J. Gaskill, Stephanie M. Matt, Pawel S. Ciborowski, Howard S. Fox
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	MDPI AG 2020-11-01
Loạt:	Viruses
Những chủ đề:	HIV SIV neuroHIV HIV-associated neurocognitive disorders (HAND) macrophage microglia
Truy cập trực tuyến:	https://www.mdpi.com/1999-4915/12/11/1297

Những quyển sách tương tự

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
Bằng: Howard S. Fox, et al.
Được phát hành: (2022-11-01)

A Rationale and Approach to the Development of Specific Treatments for HIV Associated Neurocognitive Impairment
Bằng: Aaron Scanlan, et al.
Được phát hành: (2022-11-01)

Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system
Bằng: Nikki eBortell, et al.
Được phát hành: (2015-09-01)

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
Bằng: Rachel M. Podgorski, et al.
Được phát hành: (2023-08-01)

Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats
Bằng: Yu Fu, et al.
Được phát hành: (2022-03-01)

Pitfalls of Antiretroviral Therapy: Current Status and Long-Term CNS Toxicity
Bằng: Harrison Rudd, et al.
Được phát hành: (2022-06-01)

Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain
Bằng: Maribel Donoso, et al.
Được phát hành: (2022-08-01)

HIV-1 Tat alters neuronal intrinsic excitability
Bằng: Walter Francesconi, et al.
Được phát hành: (2018-05-01)

Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
Bằng: Caitlin Tice, et al.
Được phát hành: (2020-09-01)

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
Bằng: Lindsay K Festa, et al.
Được phát hành: (2020-01-01)

Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities
Bằng: Seema Singh, et al.
Được phát hành: (2024-05-01)

Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder
Bằng: Chloe E. Meehan, et al.
Được phát hành: (2023-10-01)

Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex
Bằng: Congwu Du, et al.
Được phát hành: (2022-05-01)

Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV
Bằng: Mikki Schantell, et al.
Được phát hành: (2021-01-01)

Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV
Bằng: Michael Ilya Bukrinsky
Được phát hành: (2025-03-01)

Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.
Bằng: Jean Marie eAndrieu, et al.
Được phát hành: (2014-06-01)

Bioinformatics Study of the Interaction between Melittin Protein and P24 Protein in HIV and SIV Viruses
Bằng: Zahra Hasanshahi, et al.
Được phát hành: (2022-11-01)

The fourth major restriction factor against HIV/SIV
Bằng: Masako eNomaguchi, et al.
Được phát hành: (2011-06-01)

Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail
Bằng: Takeo eKuwata, et al.
Được phát hành: (2013-05-01)

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
Bằng: Vijayakumar Velu, et al.
Được phát hành: (2018-06-01)

HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age
Bằng: Christina E. Khodr, et al.
Được phát hành: (2022-07-01)

SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo
Bằng: Nina Derby, et al.
Được phát hành: (2024-02-01)

Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
Bằng: Olivia Harwood, et al.
Được phát hành: (2021-09-01)

Quantitative and Qualitative Distinctions between HIV-1 and SIV Reservoirs: Implications for HIV-1 Cure-Related Studies
Bằng: Joseph C. Mudd
Được phát hành: (2024-03-01)

Innate Lymphoid Cells in HIV/SIV Infections
Bằng: Spandan V. Shah, et al.
Được phát hành: (2017-12-01)

Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET
Bằng: Swati Shah, et al.
Được phát hành: (2019-05-01)

TRIM5α and species tropism of HIV/SIV
Bằng: Emi E. Nakayama, et al.
Được phát hành: (2012-01-01)

Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging
Bằng: Zoey K. Wallis, et al.
Được phát hành: (2022-02-01)

Editorial: Direct and Indirect Interactions of HIV With Host Cells
Bằng: Tetsuo Tsukamoto, et al.
Được phát hành: (2021-10-01)

Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection
Bằng: Yoelvis Garcia-Mesa, et al.
Được phát hành: (2021-03-01)

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells
Bằng: Daniel Corey, et al.
Được phát hành: (2023-03-01)

Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques
Bằng: Benjamin N. Bimber, et al.
Được phát hành: (2024-08-01)

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques
Bằng: Xintao Hu, et al.
Được phát hành: (2018-09-01)

Editorial: CD8+ T-cells in HIV/SIV infection, prophylaxis, and therapy
Bằng: Barbara L. Shacklett, et al.
Được phát hành: (2023-02-01)

Chronic Binge Alcohol and Ovarian Hormone Loss Dysregulate Circulating Immune Cell SIV Co-Receptor Expression and Mitochondrial Homeostasis in SIV-Infected Rhesus Macaques
Bằng: Patrick M. McTernan, et al.
Được phát hành: (2022-07-01)

SIV replication in human cells
Bằng: Hiroaki eTakeuchi, et al.
Được phát hành: (2012-04-01)

Macrophage Tropism in Pathogenic HIV-1 and SIV Infections
Bằng: Matthew Moeser, et al.
Được phát hành: (2020-09-01)

Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques
Bằng: Julia L Drewes, et al.
Được phát hành: (2016-12-01)

The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection
Bằng: Alexandra Melton, et al.
Được phát hành: (2024-07-01)

Systemic and Intestinal Viral Reservoirs in CD4+ T Cell Subsets in Primary SIV Infection
Bằng: Xiaolei Wang, et al.
Được phát hành: (2021-11-01)