Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein

Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein

Fullerene derivatives with hydrophilic substituents have been shown to exhibit a range of biological activities, including antiviral ones. For a long time, the anti-HIV activity of fullerene derivatives was believed to be due to their binding into the hydrophobic pocket of HIV-1 protease, thereby bl...

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Bibliographic Details
Main Authors: Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
HIV-1
fullerene
nucleocapsid
inhibition
RNA packaging
Online Access:https://www.mdpi.com/1999-4915/13/12/2451

Internet

https://www.mdpi.com/1999-4915/13/12/2451

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