Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels Pathway

Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels Pathway

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Previous studies have shown that systemic administration of 6'-hydroxy-2',4'-dimethoxychalcone (flavokawin B, FKB) exerts significant peripheral and central antinociceptive effects in laboratory animals. However, the mechanisms underlying these peripheral and central antin...

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Bibliographic Details
Main Authors: Daud Ahmad Israf, Lee Ming-Tatt, Ahmad Akira, Enoch Kumar Perimal, Nordin Lajis, Azam Shah Mohamad, Muhammad Nadeem Akhtar, Mohd Nasier Kamaldin, Mohd Roslan Sulaiman
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Molecules
Subjects:
flavokawin B
hyperalgesia
peripheral antinociceptive
nitric oxide
cyclic GMP
potassium channels
Online Access:http://www.mdpi.com/1420-3049/18/4/4209

Internet

http://www.mdpi.com/1420-3049/18/4/4209

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