Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells

Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells

Summary: CD28 provides the prototypical costimulatory signal required for productive T-cell activation. Known molecular consequences of CD28 costimulation are mostly based on studies of protein signaling molecules. The microRNA cluster miR-17∼92 is induced by T cell receptor stimulation and further...

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Bibliographic Details
Main Authors: Marianne Dölz, Marko Hasiuk, John D. Gagnon, Mara Kornete, Romina Marone, Glenn Bantug, Robin Kageyama, Christoph Hess, K. Mark Ansel, Denis Seyres, Julien Roux, Lukas T. Jeker
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Biological sciences
molecular mechanism of gene regulation
immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222016443

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http://www.sciencedirect.com/science/article/pii/S2589004222016443

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