Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics

Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics

Abstract Background First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormalities contribute to early insulin-resistance and are determined by adipocy...

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Bibliographic Details
Main Authors: Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith, Francesco Beguinot
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Clinical Epigenetics
Subjects:
Type 2 diabetes
Adipose tissue dysfunction
Epigenetic mechanisms
Mitochondrial alterations
Adipogenesis
Premature senescence
Online Access:https://doi.org/10.1186/s13148-023-01556-z

Internet

https://doi.org/10.1186/s13148-023-01556-z

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