Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

BackgroundChronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence. We hypothesized that this sex difference might be secondary to distinct activities of sex hormones on cardiomyocyte senescence, which is thought...

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Bibliographic Details
Main Authors: Paola Altieri, Chiara Barisione, Edoardo Lazzarini, Anna Garuti, Gian Paolo Bezante, Marco Canepa, Paolo Spallarossa, Carlo Gabriele Tocchetti, Sveva Bollini, Claudio Brunelli, Pietro Ameri
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiotoxicity
doxorubicin
senescence
sex
testosterone
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002383

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https://www.ahajournals.org/doi/10.1161/JAHA.115.002383

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