COX6A2 deficiency leads to cardiac remodeling in human pluripotent stem cell-derived cardiomyocytes

COX6A2 deficiency leads to cardiac remodeling in human pluripotent stem cell-derived cardiomyocytes

Abstract Background Cardiac remodeling is the initiating factor for the development of heart failure, which can result from various cardiomyopathies. Cytochrome c oxidase subunit 6A2 (COX6A2) is one of the components of cytochrome c oxidase that drives oxidative phosphorylation. The pathogenesis of...

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Bibliographic Details
Main Authors: Mengqi Jiang, Yuanxiu Song, Xi Chen, Wenjing Lu, Min Zhu, Mingyu Wei, Feng Lan, Ming Cui, Yun Bai
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Human cardiomyocyte
Cardiac remodeling
COX6A2
hiPSCs
CRISPR/Cas9
Oxidative stress
Online Access:https://doi.org/10.1186/s13287-023-03596-x

Internet

https://doi.org/10.1186/s13287-023-03596-x

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