Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes

Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes

Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong HLA associations with disease, suggest autoimmune involvement, however the links between endogenous and exogenous ri...

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Bibliographic Details
Main Authors: Aimee L. Hanson, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jennifer Walker, Wendy Stevens, Mandana Nikpour, Shervin Assassi, Susanna Proudman, Maureen D. Mayes, Tony J. Kenna, Matthew A. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Genetics
Subjects:
systemic sclerosis (scleroderma)
HLA association and disease
human disease genetics
killer immunoglobulin like receptor (KIR)
immunogenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.913196/full

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https://www.frontiersin.org/articles/10.3389/fgene.2022.913196/full

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