The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these tissues over the first three postnatal weeks, a time when the normal cortex expands and develops mature circuits. Cultu...

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Bibliographic Details
Main Authors: Qin Li, Sika Zheng, Areum Han, Chia-Ho Lin, Peter Stoilov, Xiang-Dong Fu, Douglas L Black
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-01-01
Series:eLife
Subjects:
alternative splicing
RNA binding protein
neuronal development
gene regulation
Online Access:https://elifesciences.org/articles/01201

Internet

https://elifesciences.org/articles/01201

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