A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective HIV-1 vaccine should elicit broad immune responses in order to...

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Bibliographic Details
Main Authors: Swati Jain, Gherman Uritskiy, Marthandan Mahalingam, Himanshu Batra, Subhash Chand, Hung V Trinh, Charles Beck, Woong-Hee Shin, Wadad Alsalmi, Gustavo Kijak, Leigh A Eller, Jerome Kim, Daisuke Kihara, Sodsai Tovanabutra, Guido Ferrari, Merlin L Robb, Mangala Rao, Venigalla B Rao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
hiv escape
v2 mutation
cross-reactive antibodies
combinatorial vaccine
Online Access:https://elifesciences.org/articles/92379

Internet

https://elifesciences.org/articles/92379

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