Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in adultho...

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Bibliographic Details
Main Authors: Magdalena Chojnacka, Anna Beroun, Marta Magnowska, Aleksandra Stawikowska, Dominik Cysewski, Jacek Milek, Magdalena Dziembowska, Bozena Kuzniewska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
FXS
Fmr1 KO
GluA2
AMPA receptors
synaptic plasticity
brain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1258615/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1258615/full

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