Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.

Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.

Mitochondrial dysfunction and increased oxidative stress are associated with obesity and type 2 diabetes. High fat feeding induces insulin resistance and increases skeletal muscle oxidative stress in rodents, but there is controversy as to whether skeletal muscle mitochondrial biogenesis and functio...

Full description

Bibliographic Details
Main Authors: Dorit Samocha-Bonet, Lesley V Campbell, Trevor A Mori, Kevin D Croft, Jerry R Greenfield, Nigel Turner, Leonie K Heilbronn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3346759?pdf=render

Internet

http://europepmc.org/articles/PMC3346759?pdf=render

Similar Items