Screening and evaluation of metabolites binding PRAS40 from Erxian decoction used to treat spinal cord injury

Screening and evaluation of metabolites binding PRAS40 from Erxian decoction used to treat spinal cord injury

Objective: The PRAS40 is an essential inhibitory subunit of the mTORC1 complex, which regulates autophagy. It has been suggested that Erxian Decoction (EXD) could treat spinal cord injury (SCI) via the autophagy pathway. However, the mechanism of whether EXD acts through PRAS40 remains unclear.Metho...

Full description

Bibliographic Details
Main Authors: Li Lin, Jingchuan Yan, Jin Sun, Jianfeng Zhang, Bo Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
spianl cord injury
Erxian decotion
autophagy
m-TOR
PRAS40
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1339956/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1339956/full

Similar Items