Determination of whole mixture-based potency factors for cancer risk assessment of complex environmental mixtures by in vitro testing of standard reference materials

Determination of whole mixture-based potency factors for cancer risk assessment of complex environmental mixtures by in vitro testing of standard reference materials

Whole mixture-based testing using in vitro new approach methodologies (NAMs) has been suggested to facilitate the hazard and risk assessment of complex environmental mixtures. Previous studies have shown that phosphorylation of DNA damage signaling proteins checkpoint kinase 1 (pChk1) and histone 2A...

Full description

Bibliographic Details
Main Authors: Marcos Felipe de Oliveira Galvão, Ioannis Sadiktsis, Tiago Marques Pedro, Kristian Dreij
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Environment International
Subjects:
Standard reference material
Polycyclic aromatic hydrocarbons
Mixture potency factors
DNA damage signaling
Cancer risk assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412022002720

Internet

http://www.sciencedirect.com/science/article/pii/S0160412022002720

Similar Items