Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment?

Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment?

Background: McArdle disease is caused by myophosphorylase deficiency and results in complete inability for muscle glycogen breakdown. A hallmark of this condition is muscle oxidation impairment (e.g., low peak oxygen uptake (VO2peak)), a phenomenon traditionally attributed to reduced glycolytic flux...

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Bibliographic Details
Main Authors: M. Villarreal-Salazar, A. Santalla, A. Real-Martínez, G. Nogales-Gadea, P.L. Valenzuela, C. Fiuza-Luces, A.L. Andreu, J.C. Rodríguez-Aguilera, M.A. Martín, J. Arenas, J. Vissing, A. Lucia, T.O. Krag, T. Pinós
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
McArdle disease
Skeletal muscle
Glycogen
Aerobic capacity
Cytoskeleton and mitochondrial network
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002174

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http://www.sciencedirect.com/science/article/pii/S2212877822002174

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