Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction in PDAC, yet they d...

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Bibliographic Details
Main Authors: Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad, Oliver Strobel
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Patient-derived organoids
Cancer-associated fibroblasts
Drug screening
Personalized oncology
Online Access:https://doi.org/10.1186/s13046-022-02519-7

Internet

https://doi.org/10.1186/s13046-022-02519-7

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