Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

ObjectivesUncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of the complement profile, indicative for the acti...

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Main Authors: György Sinkovits, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Zoltán Prohászka
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2 infection
mortality
severity
complement system
coronavirus disease (COVID-19)
complement activation and consumption
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663187/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.663187/full

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