CRISPR in mobile genetic elements: counter-defense, inter-element competition and RNA-guided transposition

Abstract CRISPR are adaptive immunity systems that protect bacteria and archaea from viruses and other mobile genetic elements (MGE) via an RNA-guided interference mechanism. However, in the course of the host-parasite co-evolution, CRISPR systems have been recruited by MGE themselves for counter-de...

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Bibliographic Details
Main Authors: Eugene V. Koonin, Kira S. Makarova
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-024-02090-x