Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

<p>Abstract</p> <p>HIV-1 integrase is the third enzymatic target of antiretroviral (ARV) therapy. However, few data have been published on the distribution of naturally occurring amino acid variation in this enzyme. We therefore characterized the distribution of integrase variants...

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Bibliographic Details
Main Authors: Gifford Robert J, Zioni Rafael, Kiuchi Mark, Liu Tommy F, Rhee Soo-Yon, Holmes Susan P, Shafer Robert W
Format: Article
Language:English
Published: BMC 2008-08-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/5/1/74

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