Carvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis.

Carvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis.

Periodontal diseases are initiated primarily by Gram-negative, tooth-associated microbial biofilms that elicit a host response that causes osseous and soft tissue destruction. Carvedilol is a β-blocker used as a multifunctional neurohormonal antagonist that has been shown to act not only as an anti-...

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Main Authors: Raimundo Fernandes de Araújo Júnior, Tatiana Oliveira Souza, Caroline Addison Xavier de Medeiros, Lélia Batista de Souza, Maria de Lourdes Freitas, Hévio Freitas de Lucena, Maria do Socorro Costa Feitosa Alves, Aurigena Antunes de Araújo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3700994?pdf=render

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http://europepmc.org/articles/PMC3700994?pdf=render

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