Platelet derived growth factor promotes the recovery of traumatic brain injury by inhibiting endoplasmic reticulum stress and autophagy-mediated pyroptosis

Platelet derived growth factor promotes the recovery of traumatic brain injury by inhibiting endoplasmic reticulum stress and autophagy-mediated pyroptosis

Autophagy and endoplasmic reticulum stress (ER stress) are important in numerous pathological processes in traumatic brain injury (TBI). Growing evidence has indicated that pyroptosis-associated inflammasome is involved in the pathogenesis of TBI. Platelet derived growth factor (PDGF) has been repor...

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Bibliographic Details
Main Authors: Fangfang Wu, Renkan Zhang, Weiyang Meng, Lei Liu, Yingdan Tang, Leilei Lu, Leilei Xia, Hongyu Zhang, Zhiguo Feng, Daqing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
PDGF ameliorates traumatic brain injury
PDGF
traumatic brain injury
pyroptosis
er stress
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.862324/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.862324/full

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