HILPDA is a lipotoxic marker in adipocytes that mediates the autocrine negative feedback regulation of triglyceride hydrolysis by fatty acids and alleviates cellular lipotoxic stress

HILPDA is a lipotoxic marker in adipocytes that mediates the autocrine negative feedback regulation of triglyceride hydrolysis by fatty acids and alleviates cellular lipotoxic stress

Background: Lipolysis is a key metabolic pathway in adipocytes that renders stored triglycerides available for use by other cells and tissues. Non-esterified fatty acids (NEFAs) are known to exert feedback inhibition on adipocyte lipolysis, but the underlying mechanisms have only partly been elucida...

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Bibliographic Details
Main Authors: Lei Deng, Shuangcheng Alivia Wu, Ling Qi, Sander Kersten
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Metabolism
Subjects:
HILPDA
Fatty acids
ATGL
ER stress
Autocrine negative feedback
Adipocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001072

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http://www.sciencedirect.com/science/article/pii/S2212877823001072

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