Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway

Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway

Insulin resistance (IR) is likely to induce metabolic syndrome and type 2 diabetes mellitus (T2DM). Gluconeogenesis (GNG) is a complex metabolic process that may result in glucose generation from certain non-carbohydrate substrates. Chinese herbal medicine astragalus polysaccharides and berberine ha...

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Bibliographic Details
Main Authors: Zhu-Jun Mao, Min Lin, Xin Zhang, Lu-Ping Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
astragalus polysaccharide
berberine
insulin resistance
IR-HepG2 cell model
intracellular calcium flux
gluconeogenesis signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01508/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01508/full

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