In vitro and intracellular activities of novel thiopeptide derivatives against macrolide-susceptible and macrolide-resistant Mycobacterium avium complex

In vitro and intracellular activities of novel thiopeptide derivatives against macrolide-susceptible and macrolide-resistant Mycobacterium avium complex

ABSTRACT Unsatisfactory outcomes following long-term multidrug treatment in patients with Mycobacterium avium complex (MAC) pulmonary disease have urged us to develop novel antibiotics. Thiopeptides, a class of peptide antibiotics derived from natural products, have potential as drug candidates that...

Full description

Bibliographic Details
Main Authors: Jiyun Park, Lee-Han Kim, Ju Mi Lee, Sangwon Choi, Young-Jin Son, Hee-Jong Hwang, Sung Jae Shin
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium avium complex
micrococcin p2
thiopeptide derivatives
minimum inhibitory concentration
intracellular activity
macrolide-resistant MAC
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01825-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01825-23

Similar Items