Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?

Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?

Abstract Background Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare subpopulation with the remarkable capacity to initiate, propagate and spr...

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Bibliographic Details
Main Authors: Wolfgang Gruber, Tamara Scheidt, Fritz Aberger, Christian G. Huber
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Cell Communication and Signaling
Subjects:
Cancer stem cells
Phospho-signaling
Kinases
Phosphoproteomics
Tumor cell heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12964-017-0166-1

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http://link.springer.com/article/10.1186/s12964-017-0166-1

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