Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

Abstract Background Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothelial cells (RMECs) play an imp...

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Bibliographic Details
Main Authors: Yue Guo, Ruiping Gu, Dekang Gan, Fangyuan Hu, Gang Li, Gezhi Xu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cell Communication and Signaling
Subjects:
Mitochondrial DNA
Noncanonical inflammation
cGAS–STING
Online Access:http://link.springer.com/article/10.1186/s12964-020-00637-3

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http://link.springer.com/article/10.1186/s12964-020-00637-3

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