Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Summary: Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of the influence of various culture conditions to fi...

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Bibliographic Details
Main Authors: Niklas Handin, Evgeniya Mickols, Magnus Ölander, Jakob Rudfeldt, Kristin Blom, Frida Nyberg, Wojciech Senkowski, Jozef Urdzik, Varun Maturi, Mårten Fryknäs, Per Artursson
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Biological sciences
Proteomics
Methodology in biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012037

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221012037

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