Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

Abstract Background Colibactin, a genotoxin produced by polyketide synthase harboring (pks + ) bacteria, induces double-strand breaks and chromosome aberrations. Consequently, enrichment of pks + Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large...

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Bibliographic Details
Main Authors: Diantha Terlouw, Arnoud Boot, Quinten R. Ducarmon, Sam Nooij, Manon Suerink, Monique E. van Leerdam, Demi van Egmond, Carli M. Tops, Romy D. Zwittink, Dina Ruano, Alexandra M. J. Langers, Maartje Nielsen, Tom van Wezel, Hans Morreau
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Cancer
Subjects:
Colorectal adenomas
Polyposis
Intestinal microbiology
Bacterial pathogenesis
Online Access:https://doi.org/10.1186/s12885-024-11849-y

Internet

https://doi.org/10.1186/s12885-024-11849-y

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