Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease

Abstract The causal variants and genes underlying thousands of cardiac GWAS signals have yet to be identified. Here, we leverage spatiotemporal information on 966 RNA-seq cardiac samples and perform an expression quantitative trait locus (eQTL) analysis detecting eQTLs considering both eGenes and eI...

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Bibliographic Details
Main Authors: Matteo D’Antonio, Jennifer P. Nguyen, Timothy D. Arthur, iPSCORE Consortium, Hiroko Matsui, Agnieszka D’Antonio-Chronowska, Kelly A. Frazer
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36638-2