Neutralization of Dengue Virus Serotypes by Sera from Dengue-Infected Individuals Is Preferentially Directed to Heterologous Serotypes and Not against the Autologous Serotype Present in Acute Infection

Sequential infections of humans by the four different dengue serotypes (DENV-1–4) lead to neutralizing antibodies with group, cross, and type specificity. Virus neutralization of serotypes showed monotypic but mostly multitypic neutralization profiles due to multiple virus exposures. We have studied...

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Bibliographic Details
Main Authors: Heidi Auerswald, Simone Kann, Leonard Klepsch, Janne Hülsemann, Ines Rudnik, Sebastian Schreiber, Philippe Buchy, Michael Schreiber
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/10/1957