EGFR DNA Methylation Correlates With EGFR Expression, Immune Cell Infiltration, and Overall Survival in Lung Adenocarcinoma

EGFR DNA Methylation Correlates With EGFR Expression, Immune Cell Infiltration, and Overall Survival in Lung Adenocarcinoma

BackgroundThe epidermal growth factor receptor (EGFR) is a primary target of molecular targeted therapy for lung adenocarcinoma (LUAD). The mechanisms that lead to epigenetic abnormalities of EGFR in LUAD are still unclear. The purpose of our study was to evaluate the abnormal methylation of EGFR Cp...

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Bibliographic Details
Main Authors: Zhanyu Xu, Fanglu Qin, Liqiang Yuan, Jiangbo Wei, Yu Sun, Junqi Qin, Kun Deng, Tiaozhan Zheng, Shikang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
lung adenocarcinoma
EGFR
DNA methylation
tumor biomarkers
tumor-infiltrating
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.691915/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.691915/full

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