GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression

GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression

Gpr174 is a regulator of regulatory T cells, which play an important role in angiogenesis after hindlimb ischemia. Here, the authors show GPR174-deficient Tregs promote AREG expression by inhibiting Gαs/cAMP/PKA signal pathway and increasing EGR1 nuclear accumulation to improve angiogenesis and vasc...

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Bibliographic Details
Main Authors: Jin Liu, Lihong Pan, Wenxuan Hong, Siqin Chen, Peiyuan Bai, Wei Luo, Xiaolei Sun, Furong He, Xinlin Jia, Jialiang Cai, Yingjie Chen, Kai Hu, Zhenju Song, Junbo Ge, Aijun Sun
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35159-8

Internet

https://doi.org/10.1038/s41467-022-35159-8

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