Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.

Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.

VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the...

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Main Authors: Pathum Ekanayaka, Seo-Yong Lee, Thilina U B Herath, Jae-Hoon Kim, Tae-Hwan Kim, Hyuncheol Lee, Kiramage Chathuranga, W A Gayan Chathuranga, Jong-Hyeon Park, Jong-Soo Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009057

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https://doi.org/10.1371/journal.ppat.1009057

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