Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.

Signaling through the T cell receptor (TCR) initiates adaptive immunity and its perturbation may results in autoimmunity. The plasma membrane scaffolding protein LAT acts as a central organizer of the TCR signaling machinery to activate many functional pathways. LAT-deficient mice develop an autoimm...

Full description

Bibliographic Details
Main Authors: Mogjiborahman Salek, Simon McGowan, David C Trudgian, Omer Dushek, Ben de Wet, Georgios Efstathiou, Oreste Acuto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3813684?pdf=render

Internet

http://europepmc.org/articles/PMC3813684?pdf=render

Similar Items