Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching

Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching

ABSTRACTHIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary infection and CXCR4 (X4) in chronic infection. Switching from R5 to X4 tropism in HIV-1 infection is associated with increased viral pathogenesis and disease p...

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Bibliographic Details
Main Authors: Yueyang Yu, Yi Feng, Zehua Zhou, Kang Li, Xiaoyan Hu, Lingjie Liao, Hui Xing, Yimig Shao
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
HIV-1
tropism
coreceptor-switching
C4 region
V3 loop
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2169196

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2023.2169196

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