SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages

Abstract Background Macrophages play a central role in inflammation by phagocytosing invading pathogens, apoptotic cells and debris, as well as mediating repair of tissues damaged by trauma. In order to do this, these dynamic cells generate a variety of inflammatory mediators including eicosanoids s...

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Bibliographic Details
Main Authors: Nicole Brace, Ian L. Megson, Adriano G. Rossi, Mary K. Doherty, Phillip D. Whitfield
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Inflammation
Subjects:
Online Access:https://doi.org/10.1186/s12950-022-00309-8