Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives

Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives

Genetic and environmental factors play important roles in cancer progression, metastasis, and drug resistance. Herein, we used a multiomics data analysis to evaluate the predictive and prognostic roles of genetic and epigenetic modulation of c-MET (hepatocyte growth factor receptor)/epidermal growth...

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Bibliographic Details
Main Authors: Bashir Lawal, Yu-Chi Wang, Alexander T. H. Wu, Hsu-Shan Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
genetic and epigenetic alterations
cancer-associated fibroblast
immune infiltration
small molecule
NSC777205
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691234/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.691234/full

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