Synovium microenvironment-responsive injectable hydrogel inducing modulation of macrophages and elimination of synovial fibroblasts for enhanced treatment of rheumatoid arthritis

Synovium microenvironment-responsive injectable hydrogel inducing modulation of macrophages and elimination of synovial fibroblasts for enhanced treatment of rheumatoid arthritis

Abstract Rheumatoid arthritis (RA) is a progressive autoimmune disease accompanied by joint swelling, cartilage erosion and bone damage. Drug therapy for RA has been restricted due to poor therapeutic effect, recurrence and adverse effects. Macrophages and synovial fibroblasts both play important ro...

Full description

Bibliographic Details
Main Authors: Yiqun Wu, Yu Ge, Zhongshi Wang, Ying Zhu, Tianli Tian, Jun Wei, Yu Jin, Yi Zhao, Qiang jia, Jun Wu, Liang Ge
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Rheumatoid arthritis
Bismuthene nanosheet
pH sensitive injectable hydrogel
Synovial fibroblasts
Modulation of macrophage
Online Access:https://doi.org/10.1186/s12951-024-02465-w

Internet

https://doi.org/10.1186/s12951-024-02465-w

Similar Items