Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion

Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion

To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in pharmaceutical applications, necessitates exte...

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Bibliographic Details
Main Authors: Martin Spoerk, Ioannis Koutsamanis, Josip Matić, Simone Eder, Carolina Patricia Alva Zúñiga, Johannes Poms, Jesús Alberto Afonso Urich, Raymar Andreína Lara García, Klaus Nickisch, Karin Eggenreich, Andreas Berghaus, Kathrin Reusch, Yorick Relle, Johannes Khinast, Amrit Paudel
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
cleaning verification
cleaning-in-place
hot melt extrusion
API contamination
UV–Vis spectroscopy
process analytical technology
Online Access:https://www.mdpi.com/1999-4923/12/6/588

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https://www.mdpi.com/1999-4923/12/6/588

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