LAMP1 targeting of the large T antigen of Merkel cell polyomavirus results in potent CD4 T cell responses and tumor inhibition

LAMP1 targeting of the large T antigen of Merkel cell polyomavirus results in potent CD4 T cell responses and tumor inhibition

IntroductionMost cases of Merkel cell carcinoma (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV integrates into the host genome, resulting in expression of oncoproteins including a truncated form of the vir...

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Bibliographic Details
Main Authors: Claire Buchta Rosean, Erica C. Leyder, Jeneice Hamilton, Joseph J. Carter, Denise A. Galloway, David M. Koelle, Paul Nghiem, Teri Heiland
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
cancer vaccine
Merkel cell polyomavirus
Merkel cell carcinoma
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253568/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253568/full

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