A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

Abstract Background Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities. Therefore, an in silico humanization method that can prevent the loss of the binding affinity of mAbs is needed....

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Bibliographic Details
Main Authors: Yuan-Chin Hsieh, Jun-min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Nanobiotechnology
Subjects:
Antibody
Humanized antibody
TNF-α
Root mean squared deviation (RMSD)
Molecular dynamics
Online Access:https://doi.org/10.1186/s12951-022-01259-2

Internet

https://doi.org/10.1186/s12951-022-01259-2

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