A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies
Abstract Background Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities. Therefore, an in silico humanization method that can prevent the loss of the binding affinity of mAbs is needed....
Main Authors: | Yuan-Chin Hsieh, Jun-min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-01-01
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Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-022-01259-2 |
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