Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-10-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC6192650?pdf=render |